Ribosomal protein S2 pseudogene 52 (RPS2P52)

Ribosomal protein S2 pseudogene 52 (RPS2P52) is a non-coding DNA sequence in the human genome that shares high sequence similarity with the functional ribosomal protein S2 gene but lacks the capability to produce a functional protein[5][8]. Such pseudogenes result from gene duplication, retrotransposition, or incomplete copying events, and their sequences often contain disabling mutations that prevent translation into a working protein. RPS2P52 does not participate in canonical ribosome synthesis, signaling, or known cellular functions. It is not recognized as a therapeutic target, receptor, enzyme, transporter, transcription factor, or disease biomarker. Its designation as a "pseudogene" indicates that it is not a protein-coding gene, but rather a genomic remnant of evolutionary origin[5][8]. Ribosomal protein pseudogenes, including RPS2P52, are commonly dispersed throughout the genome; they typically have no direct functional effects and are not included in clinical or pharmacological targeting[5]. There may be confusion or misidentification between protein-coding ribosomal subunits (such as RPS2) and their pseudogenes; only the protein-coding forms participate in ribosomal function or are occasionally implicated in disease[1][4][5]. The canonical ribosomal protein S2 (RPS2), not RPS2P52, is the true component of the 40S ribosomal subunit and plays roles in translation and ribosome assembly[1][4][9]. RPS2P52 should not be considered a valid therapeutic target. If you need structured information for the functional ribosomal protein S2, refer to "Ribosomal protein S2" (RPS2), a genuine protein-coding gene with known molecular and disease roles[1][4][9].

Other names

RPS2_23_1615RPS2P52