Ribosomal protein S21 pseudogene (RPS21P)

Ribosomal protein S21 pseudogene refers to a genomic DNA sequence resembling the gene encoding ribosomal protein S21 but lacking the capacity to code for a functional protein. Pseudogenes are considered molecular fossils—remnants of once-active genes that have accumulated mutations resulting in loss of function, such as premature stop codons or frameshifts[11][2]. There are multiple processed pseudogenes for ribosomal protein S21 distributed throughout the human genome[11][2]. These pseudogenes do not encode functional ribosomal proteins, are not transcribed into functional RNA or protein, and have no direct role in cell biology, therapy, or disease[11][2][1]. Their presence is sometimes used in genome structure analysis or as evolutionary markers. The canonical functional gene is RPS21 (ribosomal protein S21), a component of the 40S small ribosomal subunit responsible for protein synthesis in the cytoplasm[1][10][12]. Note: If you are seeking information about the protein-coding ribosomal protein S21 gene (RPS21, ENSG00000171858), it is a small ribosomal subunit protein involved in translation, but its pseudogenes are not therapeutic targets[1][10][7].

Other names

RPS21 pseudogeneribosomal protein S21 pseudogeneRPS21PENSG00000230603

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