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Target intelligence / Profile preview
Ribosomal protein S24 (RPS24)
- Target
- RPS24
- Molecular classification
- Other (ribosomal protein, structural component of ribosome)
01
Overview
Ribosomal protein S24 is a component of the small (40S) ribosomal subunit, crucial for cellular protein synthesis. It is encoded by the RPS24 gene located on chromosome 10. RPS24 takes part in the maturation and processing of pre-rRNA and assembly of the small ribosomal subunit[1][2][3][6]. Besides its primary structural and translational role, ribosomal protein S24 has been implicated in the regulation of cell division and apoptosis. Mutations in RPS24 are associated with Diamond-Blackfan anemia, a rare congenital bone marrow failure characterized by anemia and physical anomalies. Recent research suggests alternative splicing of RPS24 may be linked to cancer biology, but it is not currently recognized as a direct therapeutic target for drug development[2][5].
- Other names
- 40S ribosomal protein S24small ribosomal subunit protein eS24DBA3S24eS24RS24_HUMAN
02
Biological functions
Protein synthesisRibosome assemblyPre-rRNA processingCell division regulationApoptosis (programmed cell death) regulation
03
Disease associations
Diamond-Blackfan anemiaPossibly cancer (alternative splicing and changes in expression may be markers of cancer progression)
04
Safety considerations
Mutations in RPS24 can lead to increased apoptosis of blood-forming cells, contributing to Diamond-Blackfan anemia
05
Biomarkers
Alternative splicing of RPS24 is noted as a marker of cancer progression and epithelial-mesenchymal transition
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