Ribosomal protein S25 (RPS25)

Ribosomal protein S25 (RPS25) is a eukaryote-specific protein component of the small 40S ribosomal subunit, belonging to the S25E family and encoded by the RPS25 gene[2][4][5]. It is primarily localized in the cytoplasm and plays a key structural role in ribosome integrity and protein synthesis. RPS25 is required for efficient translation via internal ribosome entry sites (IRES) and ribosome shunting, mechanisms exploited by cellular and viral RNAs for protein expression[3]. It participates in a regulatory feedback loop with MDM2 and p53, influencing cell cycle, apoptosis, and tumorigenesis[1]. RPS25 has been implicated in neurodegenerative diseases, especially in facilitating unconventional RAN translation in nucleotide repeat expansion disorders like ALS and FTD[1]. While not essential for basic cell viability, RPS25 plays multiple regulatory roles impacting stress responses, cell proliferation, and resistance phenotypes[1][3][4].

Other names

Small ribosomal subunit protein eS25eS25S2540S ribosomal protein S25ribosomal protein S25

Inhibition of RPS25 affects IRES-mediated viral translation, reducing viral replication (e.g., adenovirus, HCV) Modulation of p53 stabilization by interfering with the RPS25–MDM2 feedback loop RPS25 depletion influences cellular resistance to toxins and viruses