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Target intelligence / Profile preview
Ribosomal protein S26 pseudogene 21 (RPS26P21)
- Target
- RPS26P21
- Molecular classification
- Pseudogene, Non-coding RNA locus
01
Overview
Ribosomal protein S26 pseudogene 21 (RPS26P21) is one of many processed pseudogenes of the ribosomal protein S26 (RPS26) gene in the human genome[3][4][6][8]. Pseudogenes arise from the duplication and reverse transcription of functional genes but typically acquire disabling mutations that prevent them from encoding functional proteins[4]. RPS26P21 is not believed to express any protein or have a defined biological function. The functional gene RPS26 encodes a component of the small (40S) ribosomal subunit and is vital for protein synthesis, with mutations in RPS26 causing Diamond-Blackfan anemia, but the pseudogene does not share these disease roles[5][7][9].
- Other names
- RPS26_3_394RPS26P21Ribosomal protein S26 pseudogene 21
02
Mechanism of action
Not applicable. No drugs act via this pseudogene
03
Biological functions
As a pseudogene, it is not known to produce a functional protein or have active roles in ribosome function or other canonical cellular functionsMost pseudogenes are considered non-functional genomic elements, but some may have regulatory functions (such as acting as competing endogenous RNAs or producing non-coding RNA transcripts that affect gene regulation); however, there is no published functional role for RPS26P21 specifically
04
Disease associations
None directly attributed; pseudogenes themselves are generally not associated with disease, but some pseudogenes may modulate the expression of their parent genes in rare casesDiseases such as Diamond-Blackfan anemia are associated with mutations in the functional RPS26 gene, but not in this pseudogene
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