Ribosomal protein S28 pseudogene

Ribosomal protein S28 pseudogenes are non-coding genomic loci derived from the parental ribosomal protein S28 gene via duplication or retrotransposition. They do not produce functional protein products, but accumulating evidence suggests their long non-coding RNAs may act as competitive endogenous RNAs (ceRNAs), binding and sequestering microRNAs that would otherwise regulate the parental RPS28 gene. For example, increased expression of some ribosomal protein S28 pseudogenes (e.g., RPS28P7) has been associated with cancer progression, likely by up-regulating the parental RPS28 protein via miRNA sponging. These pseudogenes are not considered traditional drug targets, but emerging research proposes their RNA may represent a novel class of regulatory molecules and possible biomarkers or experimental RNA therapeutic targets in some cancers. This entry is not a protein-coding ribosomal subunit or traditional therapeutic target. If you are seeking information on the functional protein (ribosomal protein S28, gene symbol RPS28), refer instead to RPS28/ENSG00000233927. The "ribosomal protein S28 pseudogene" refers to one of several pseudogenes, not to an active molecular target.

None established. A hypothetical approach is using small molecules or RNA therapies to degrade the pseudogene transcript to modulate miRNA regulation of parental protein-coding genes.