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Ribosomal protein S3 pseudogene 6 (**RPS3P6**) is one of several pseudogenes derived from the canonical ribosomal protein S3 gene. Pseudogenes are typically non-functional segments of DNA that resemble functional genes but lack the ability to encode active proteins. RPS3P6 is classified and approved as a pseudogene by the HUGO Gene Nomenclature Committee (HGNC:36061)[2]. Unlike the functional ribosomal protein S3, which is a component of the 40S ribosomal subunit involved in protein synthesis and DNA repair, pseudogenes such as RPS3P6 are not involved in cellular processes or disease mechanisms[1][2]. They do not participate in drug interactions or serve as therapeutic targets. The existence of RPS3P6 reflects genomic duplication and processing events common for ribosomal protein genes in humans, which often produce multiple pseudogenes scattered throughout the genome[1]. When searching for functional or disease-relevant information, reference should be made to the canonical "Ribosomal protein S3" (RPS3), not its pseudogenes[1][2].
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