Ribosomal protein S4, X-linked pseudogene 22 (RPS4XP22)

Ribosomal protein S4, X-linked pseudogene 22 (RPS4XP22) is a processed pseudogene found in the human genome, most commonly referenced in gene databases such as NCBI (Gene ID: 100131614) and Ensembl (ENSG00000239830)[3][5]. Pseudogenes like RPS4XP22 result from duplication or retrotransposition of their parent protein-coding genes but lack the ability to produce functional proteins, generally due to mutations such as frameshifts or premature stop codons. Unlike its parent gene RPS4X, which encodes a structural component of the ribosome, RPS4XP22 is not translated into a functional ribosomal protein. There is no evidence that RPS4XP22 acts as a therapeutic target, biomarker, or interacts with drugs. It is not documented as having a role in any disease and is not categorized as a standard molecular target class like enzyme, receptor, or ion channel. Although some ribosomal protein pseudogenes have been shown to have regulatory functions or disease associations (e.g., in cancer), there is no published functional or clinical information for RPS4XP22 specifically[8]. The presence of multiple ribosomal protein S4X pseudogenes (such as those numbered 1–22) is a common feature of the human genome, but most are nonfunctional and not involved in physiologically relevant processes[5][7]. RPS4XP22 is a pseudogene, not a protein-coding gene, therapeutic target, nor a receptor. It is not misspelled, but it does not meet criteria as a valid therapeutic or research drug target. The entry is correct as a gene locus but incorrect/not applicable for therapeutic targeting.

Other names

RPS4XP22RPS4P22RPS4X_8_1621ribosomal protein S4, X-linked pseudogene