Ribosomal protein S4 Y-linked 1 (RPS4Y1)

Ribosomal protein S4 Y-linked 1 (RPS4Y1) is a protein encoded by the RPS4Y1 gene in humans and is a structural component of the small 40S subunit of cytoplasmic ribosomes, which are essential for catalyzing protein synthesis. RPS4Y1 is one of several isoforms of ribosomal protein S4, unique among ribosomal proteins because it is encoded by more than one gene—RPS4Y1 (Y chromosome), RPS4Y2 (Y chromosome, testis-specific), and RPS4X (X chromosome). The protein participates in RNA binding and assembling the ribosomal machinery for translation. While largely functionally redundant with the X-linked form, RPS4Y1 is retained in the male genome likely for gene dosage compensation. There is suggestive but disputed evidence associating haploinsufficiency of these genes with Turner syndrome. RPS4Y1 does not appear to be a direct therapeutic target, nor are there known drug interactions, biomarker roles, or safety/tolerability issues reported[1][2][3][4][5].

Other names

Small ribosomal subunit protein eS4, Y isoform 1RPS4YPRO2646MGC5070MGC119100S440S ribosomal protein S4Ribosomal protein S4Y40S ribosomal protein S4, YRibosomal protein S4, Y-linkedSmall ribosomal subunit protein eS4, YSmall ribosomal subunit protein eS4