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Target intelligence / Profile preview
Ribosomal Protein S6 Kinase (S6K)
- Target
- S6K
- Molecular classification
- Serine/threonine kinase, AGC kinase family
01
Overview
Ribosomal Protein S6 Kinase (S6K) is a family of serine/threonine kinases crucial for regulating protein synthesis, cell growth, and metabolism. The most studied forms, S6K1 and S6K2, are activated by the mTORC1 pathway in response to growth factors, nutrients, and energy status. S6Ks enhance translation initiation by phosphorylating rpS6 and influence glucose homeostasis and lipid synthesis. Dysregulation of S6K is linked to obesity, diabetes, aging, and cancer, making it a potential therapeutic target.
- Other names
- p70 S6 kinaseS6K1S6K2
02
Mechanism of action
Inhibition of S6K phosphorylation of ribosomal protein S6 and other downstream targets, leading to reduced protein synthesis and cell growth.
03
Biological functions
Protein synthesisCell growthGlucose homeostasisMetabolismTranslation initiation
04
Disease associations
ObesityDiabetesAgingCancer
05
Safety considerations
Potential for off-target effects due to kinase family similaritiesEffects on glucose metabolism and insulin sensitivity need careful monitoringLong-term effects on aging processes are not fully understood
06
Interacting drugs
Rapamycin
2 more in the full profile.
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