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Target intelligence / Profile preview
Ribosomal protein S6 kinase 1 (S6K1)
- Target
- S6K1
- Molecular classification
- Enzyme, Serine/threonine kinase, Kinase
01
Overview
Ribosomal protein S6 kinase 1 (S6K1) is a serine/threonine kinase that phosphorylates ribosomal protein S6, promoting translation initiation and cell growth. It is a key downstream target of the PI3K/AKT/mTOR signaling pathway and is implicated in various diseases, including cancer, obesity, and diabetes. S6K1's activation is primarily regulated by mTORC1-mediated phosphorylation at Thr389. It also plays roles in mRNA processing, glucose homeostasis, and stress response.
- Other names
- p70S6 kinasep70S6Kribosomal protein S6 kinase beta-1
02
Mechanism of action
mTORC1 inhibition leading to decreased S6K1 phosphorylation and activity.
03
Biological functions
Translation initiationCell growth regulationCell proliferationGlucose homeostasismRNA processingStress responseRegulation of cell sizeCell survival
04
Disease associations
CancerObesityDiabetesAging
05
Safety considerations
Potential for off-target effects due to kinase family similarityPossible disruption of normal cellular processes regulated by S6K1May have implications for adipocyte formation
06
Biomarkers
Phosphorylation status of Thr389Expression levels of S6K1
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