Ribosomal protein S6 kinase A5 (RPS6KA5)

Ribosomal protein S6 kinase A5 (RPS6KA5, also called MSK1) is a serine/threonine-protein kinase encoded on human chromosome 14 and part of the ribosomal S6 kinase family. It transduces signals from mitogens and cellular stress to a range of transcription factors and histone proteins via phosphorylation. RPS6KA5 modulates gene activation, influences immune and inflammatory responses, and has been implicated in multiple pathways related to cancer biology, neurological processes, and development. Its activities are critical for proper cell signaling, transcriptional regulation, and stress-adaptive gene expression; dysregulation may influence pathologies such as cancer, inflammatory disease, and rare genetic syndromes.

Other names

RPS6KA5Ribosomal protein S6 kinase alpha-590 kDa ribosomal protein S6 kinase 5MSK1 (Mitogen- and stress-activated kinase 1)RSK-like protein kinaseRSKLS6K-alpha-5MSPK1RLPKRLSK3110005L17RIK6330404E13Rik

For hypothetical or investigational inhibitors, the mechanism of action could involve competitive inhibition of ATP binding, blockage of kinase activity, suppression of downstream phosphorylation events (e.g., of transcription factors, histones), and attenuation of pro-inflammatory or proliferative signaling pathways.