Drug pipeline
Full profile accessExplore the programs pursuing this target and their development progress.
- Drug candidates
- Developers
- Development stage
Target intelligence / Profile preview
Ribosomal protein S6 kinase alpha-3 (RPS6KA3)
- Target
- RPS6KA3
- Molecular classification
- Serine/threonine-protein kinase, Enzyme
01
Overview
Ribosomal protein S6 kinase 3 (RPS6KA3) is a serine/threonine kinase that plays a crucial role in regulating cell growth, proliferation, survival, and metabolism. It is activated downstream of the MAPK/ERK signaling cascade and phosphorylates various substrates, including ribosomal protein S6 (rpS6) and transcription factors like CREB. Mutations in RPS6KA3 are associated with Coffin-Lowry syndrome, and aberrant activation or inhibition can contribute to tumorigenesis or metabolic syndromes.
- Other names
- p90 ribosomal S6 kinaseMAPKAP-K1
02
Mechanism of action
Kinase inhibition
03
Biological functions
Signal transductionCell growthCell proliferationCell survivalRegulation of transcriptionNegative feedback regulation of MAPK pathway
04
Disease associations
Coffin-Lowry syndromeCancerMetabolic disorders
Beyond the preview
Go deeper on Ribosomal protein S6 kinase alpha-3 (RPS6KA3).
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Clinical trials
Full profile accessFollow the clinical studies evaluating therapies directed at this target.
- Trial design
- Status
- Readouts
Competitive landscape
Full profile accessCompare approaches across drug candidates, modalities, and indications.
- Programs
- Modalities
- Indications
Literature & evidence
Full profile accessInvestigate the research and source evidence behind target biology and development.
- Publications
- Sources
- Analysis
Patents
Full profile accessExplore patent activity around therapies and technologies addressing this target.
- Patents
- Assignees
- Technologies
Research & analysis
Full profile accessConnect target biology, drug development, and emerging evidence in your research.
- Biology
- Development news
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on Ribosomal protein S6 kinase alpha-3 (RPS6KA3).