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Ribosomal protein S6 kinase alpha-6 (RPS6KA6)
- Target
- RPS6KA6
- Molecular classification
- Enzyme, Serine/threonine-protein kinase, Ribosomal S6 kinase family
01
Overview
Ribosomal protein S6 kinase alpha-6 (RPS6KA6) is a constitutively active serine/threonine-protein kinase belonging to the ribosomal S6 kinase family, with growth-factor-independent kinase activity. It has been implicated in regulation of cell proliferation and may participate in p53/TP53-dependent signaling pathways related to tumor suppression, although its exact roles appear distinct from other RSK family members. This protein is expressed in multiple tissues and may act as a negative regulator of cellular growth pathways, including possible regulation of the ERK1/2 MAP kinase cascade[1][4][7][8].
- Other names
- RSK4p90-RSK 6p90RSK690 kDa ribosomal protein S6 kinase 6ribosomal S6 kinase 4S6K-alpha-6PP90RSK4
02
Biological functions
Signal transductionCell proliferationRegulation of p53/TP53-dependent cellular senescence and apoptosisIntracellular signal transductionLikely negative regulation of the ERK pathway (mainly based on rodent orthologs)
03
Disease associations
CancerOther (potentially implicated in tumor suppression and regulation of cell fate)
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