Ribosomal protein S6 kinase B1 (p70S6K1)

Ribosomal protein S6 kinase B1 (p70S6K1) is a serine/threonine kinase regulated downstream of the phosphoinositide 3-kinase (PI3K)-mTOR pathway that phosphorylates ribosomal protein S6, affecting selective translation of 5'TOP mRNAs. It plays a central role in cell growth, proliferation, and metabolism, and is implicated in the development of cancer, diabetes, and other proliferative diseases. Due to its pivotal function in protein synthesis and frequent dysregulation in human disease, p70S6K1 is considered an important therapeutic target and biomarker for responses to mTOR inhibitors in oncology and immunosuppressive therapy.

Other names

p70 ribosomal S6 kinase 1p70S6KS6Kβ1ribosomal protein S6 kinase, 70 kDa, polypeptide 1ribosomal protein S6 kinase alpharibosomal protein S6 kinase beta-1ribosomal protein S6 kinase IS6 kinaseSTK14ARPS6KB1

Inhibition of kinase activity, blocking phosphorylation of ribosomal protein S6, interference with mTOR signaling, reduction in protein synthesis, modulation of cell growth and proliferation