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Ribosomal Protein S6 Kinase Beta‑1 (p70S6K)
- Target
- p70S6K
- Molecular classification
- Enzyme, Serine/threonine-specific protein kinase
01
Overview
Ribosomal protein S6 kinase beta-1 (p70S6K), encoded by the RPS6KB1 gene, is a serine/threonine kinase that regulates cell growth, proliferation, survival, and protein synthesis. It is a key downstream effector of the PI3K-Akt-mTOR pathway, primarily acting through mTORC1. p70S6K phosphorylates ribosomal protein S6, promoting increased translation and global protein synthesis. It also phosphorylates other substrates like EIF4B and EEF2K, influencing translational control and cell survival. Aberrant expression or activation of p70S6K is implicated in cancer development and other diseases.
- Other names
- RPS6KB1S6K1p70(S6)k-alphaPS6KASTK14Ap70-S6KA-alpha
02
Mechanism of action
Kinase inhibitor (of RPS6KB1)
03
Biological functions
Cell growthCell proliferationProtein synthesisApoptosis regulationAutophagy regulationCell cycle progressionSignal transductionRibosome biogenesis
04
Disease associations
CancerHypertrophic cardiomyopathy
05
Safety considerations
Potential for off-target effects due to involvement in multiple signaling pathwaysTumorigenesis with overexpression or gene amplification
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