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Target intelligence / Profile preview
Ribosomal Protein S6 Kinase Beta 1 (p70S6K)
- Target
- p70S6K
- Molecular classification
- Serine/threonine kinase, Enzyme
01
Overview
Ribosomal protein S6 kinase beta 1 (p70S6K) is a serine/threonine kinase that plays crucial roles in cell growth, proliferation, and survival. It functions downstream of the PI3K/mTOR signaling pathway and is involved in regulating protein synthesis, cell cycle progression, and cellular motility. Dysregulation of p70S6K has been implicated in various pathological conditions, including cancer, metabolic disorders, fibrosis, and aging, making it an important therapeutic target and biomarker.
- Other names
- S6K1S6KRPS6KB170 kDa ribosomal protein S6 kinase
02
Mechanism of action
Inhibition of p70S6K activity, thereby reducing protein synthesis and cell growth.
03
Biological functions
Protein synthesis regulationCell growthCell proliferationCell motilityRegulation of translationCell cycle progressionMetabolism regulation
04
Disease associations
CancerMetabolic disordersType 2 diabetesObesityFibrosisAgingTumor metastasis
05
Safety considerations
Narrow therapeutic index of mTOR inhibitorsPotential for metabolic side effects
06
Interacting drugs
mTOR inhibitors
1 more in the full profile.
07
Biomarkers
Plasma p70S6K levels (for monitoring response to mTOR inhibitors)p70S6K phosphorylation status
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