Ribosomal protein S6 kinase beta-2 (S6K2)

Ribosomal protein S6 kinase beta-2 (S6K2) is a serine/threonine-protein kinase encoded by the RPS6KB2 gene on chromosome 11 (11q13)[1]. It belongs to the AGC kinase family and functions predominantly downstream of the mTOR signaling pathway, phosphorylating ribosomal protein S6 in response to growth factors and nutrients[7][6]. S6K2 differs from its close relative S6K1 in nuclear localization and regulatory motifs, owing to a unique nuclear localization sequence and proline-rich domain, conferring distinctive cellular distribution and interactions[1][2]. It plays major roles in regulating protein synthesis, cell growth, metabolism, immune cell differentiation, and genome stability, and has been implicated in several diseases, including cancer, metabolic syndromes, and neurological dysfunctions. S6K2 interacts with SPRED2 to modulate MAPK pathway signaling and regulates other proteins such as RORγ for immune differentiation[4][1]. Its central role in cell proliferation and survival makes it of interest as a therapeutic target, particularly in oncology and disorders involving mTOR pathway dysregulation.

Other names

S6K2Ribosomal S6 kinase 2p70 S6 kinase beta-2RPS6KB2

Inhibition of kinase activity (S6K2 inhibitors); Modulation of mTOR pathway signaling; Interference with phosphorylation of downstream targets (e.g., ribosomal protein S6, YB1, CREB)