Ribosomal protein S6 pseudogene

The ribosomal protein S6 pseudogene (ENSG00000214908) is a genomic sequence similar to the functional ribosomal protein S6 (RPS6) gene, but it is categorized as a pseudogene due to disruptions or lack of regulatory elements that prevent it from producing a functional protein[4][7]. While the parental RPS6 is part of the small (40S) subunit of the ribosome with critical roles in protein synthesis, cell growth, and proliferation[3][5], its pseudogenes are typically non-functional remnants within the genome, often arising from genomic duplication or retrotransposition events[1][7]. Most pseudogenes, including ribosomal protein S6 pseudogenes, have no established biological or disease roles, though in rare cases, some may act through RNA-mediated regulatory mechanisms with their parental gene[4][7]. Use of pseudogene entries as drug targets is not appropriate unless there is experimental evidence for a regulatory or functional role[4]. Ribosomal protein S6 pseudogenes are nonfunctional gene copies related to the ribosomal protein S6, which itself has well-defined cellular functions[3]. Pseudogenes are generally not therapeutic targets and should be considered incorrect/invalid as molecular drug targets unless compelling new data demonstrate a regulatory or functional role[4][7]. The most accurate naming for such targets is "Ribosomal protein S6 pseudogene" without a canonical abbreviation or active target role.

Other names

RPS6PRPS6P(XX)