Ribosomal protein SA pseudogene 26 (RPSAP26)

Ribosomal protein SA pseudogene 26 (RPSAP26) is a **pseudogene** related to the functional RPSA gene (ribosomal protein SA), which encodes the 40S ribosomal protein SA, a component of the small ribosomal subunit in eukaryotes[2][1]. RPSAP26 is identified as an **intergenic, non-protein-coding sequence** and is classified among a larger family of RPSA pseudogenes found in ruminant genomes, such as sheep and cattle[1][2]. Pseudogenes like RPSAP26 derive from retrotransposition or gene duplication events of ancestral protein-coding genes but typically lack the ability to encode a functional product due to frameshift mutations, premature stop codons, or deletions[1]. Current evidence does not support RPSAP26 being transcribed into a functional RNA or translated into protein, nor is there any known biological or disease association for this pseudogene[2][1]. Pseudogenes generally are not considered therapeutic targets, do not serve as biomarkers, and do not interact with drugs. RPSAP26 should not be confused with the functional parent gene **ribosomal protein SA (RPSA)**, which is involved in ribosome assembly, protein synthesis, cell adhesion, and disease processes such as cancer and prion disease[1][3][5].

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