Ribosomal protein SA pseudogene 3 (RPSAP3)

Ribosomal protein SA pseudogene 3 (RPSAP3) is a processed pseudogene related to the ribosomal protein SA (also known as 37-kDa laminin receptor precursor/67-kDa laminin receptor). Unlike the canonical coding gene, RPSAP3 does not produce a functional protein, but may function as a long non-coding RNA (lncRNA). Recent research indicates RPSAP3, like other pseudogenes, may regulate gene expression post-transcriptionally. For example, in animal models of Alzheimer’s disease, the pseudogene known as Lamr1-ps1 (homologous to RPSAP3) exacerbates early spatial learning and memory deficits by acting through the miR-29c/Bace1 signaling pathway, suggesting a specific regulatory lncRNA-like role in neuronal cells. Overall, RPSAP3 should not be considered a therapeutic target in the sense of a receptor, enzyme, transporter or canonical drug target, but may be explored as part of disease-modifying pathways in certain neurodegenerative models. The gene is classified as a pseudogene and not a canonical protein target, so standard classifications such as receptor, enzyme, or transporter do not apply[1][2][4]. Key details: - **RPSAP3 is a pseudogene, not a protein-coding gene or direct druggable target**[1][4]. - **It does not function as a receptor or participate in classic signal transduction, transport, or enzymatic activity**. - **Some literature describes regulatory RNA-like effects in neurodegenerative models, but this does not confer standard "target" status as used in drug development**[2]. - **No direct interacting drugs, mechanisms of action, or clinical biomarkers are associated**. Any link to disease involves possible modulation of other genes through RNA-mediated effects, not direct targeting[2]. If a canonical therapeutic target is sought, the parent gene/protein "Ribosomal protein SA" (RPSA; also known as 67-kDa laminin receptor) should be considered instead[5].

Other names

LAMR1P3RPSA_21_1392laminin receptor 1 pseudogene 3LAMR1-PS3