Ribosomal protein SA pseudogene 33 (RPSAP33)

Ribosomal protein SA pseudogene 33 (RPSAP33) is a pseudogene—an inactive segment of DNA that resembles a gene but generally does not encode a functional protein. It is related to the RPSA gene, which codes for the functional ribosomal protein SA (also known as 37-kDa laminin receptor precursor/67-kDa laminin receptor). The functional RPSA protein plays roles in ribosome biogenesis and acts as a cell surface receptor for laminin, participating in processes like cell adhesion and tumor metastasis[7][9][11]. Pseudogenes like RPSAP33 arise by duplication or retrotransposition events and accumulate disabling mutations that prevent normal protein expression[9]. There is no evidence that RPSAP33 itself is a protein-coding gene, a molecular target, or has therapeutic relevance, nor is it associated with any drug activity or disease mechanism[5][9]. Thus, it is not considered a therapeutic target, and its inclusion on target lists is likely an error due to confusion with the functional RPSA gene. Key clarification: RPSAP33 is a pseudogene, not a protein-coding gene nor a functional molecular target. The functionally significant molecule in biology and medicine is ribosomal protein SA (RPSA), not RPSAP33[5][7][9][11].

Other names

RPSA_10_433RPSAP33