Ribosomal protein SA pseudogene 53 (RPSAP53)

Ribosomal protein SA pseudogene 53 (RPSAP53) is a human pseudogene, a noncoding genomic sequence originally related to the ribosomal protein SA gene. Unlike its parent gene (RPSA), which encodes a cell surface laminin receptor implicated in tumor invasion, metastasis, and prion disease pathology[2][3], RPSAP53 does not encode a functional protein. Recent research suggests that the expression of certain pseudogenes, including RPSAP53, may have prognostic and biomarker value in cancer, such as melanoma, where higher levels appear correlated with better survival and altered immune cell infiltration in tumors[4]. However, it is not considered a canonical drug target and is not known to interact directly with any therapeutic agents. Note: There is substantial risk of conflating RPSAP53 with RPSA (ribosomal protein SA), which is an established multifunctional protein and receptor. For most drug discovery and pharmacological databases, pseudogenes such as RPSAP53 are not listed as targets unless there is robust evidence of functional protein expression or direct drug interaction. RPSAP53 should therefore be classified as a noncoding RNA with emerging biomarker potential but not as a canonical therapeutic target.

Other names

RPSAP53RPSA_19_1317Ribosomal protein SA pseudogene 53

None (not a protein target; no drug mechanism defined)