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Ribosomal RNA (rRNA)
- Target
- rRNA
- Molecular classification
- Non-coding RNA
01
Overview
Ribosomal RNA (rRNA) is a non-coding RNA that forms the structural and catalytic core of ribosomes, essential for protein synthesis. It facilitates peptide bond formation, aligns mRNA and tRNA, and provides structural support for the ribosome. rRNA is targeted by several antibiotics to disrupt bacterial protein synthesis. Emerging research suggests novel roles in micro-RNA production involved in inflammation/cardiovascular disease responses.
- Other names
- rRNAsRibosomal ribonucleic acid
02
Mechanism of action
Inhibition of bacterial ribosome function, disruption of rRNA structure and function
03
Biological functions
Protein synthesisPeptide bond formationmRNA bindingtRNA bindingRibosome structural component
04
Disease associations
InfectionCardiovascular diseaseInflammation
05
Safety considerations
Off-target effects on eukaryotic ribosomes (mitochondrial ribosomes)Antibiotic resistance
06
Interacting drugs
Streptomycin
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