Drug pipeline
Full profile accessExplore the programs pursuing this target and their development progress.
- Drug candidates
- Developers
- Development stage
Target intelligence / Profile preview
Ribosomal RNA from Lactobacillus (rRNA (not specific to Lactobacillus, but used for ribosomal RNA generally))
- Target
- rRNA (not specific to Lactobacillus, but used for ribosomal RNA generally)
- Molecular classification
- Ribonucleic acid (RNA), Non-coding RNA, Ribosomal RNA, Catalytic RNA (Ribozyme)
01
Overview
Ribosomal RNA from *Lactobacillus* comprises several types: 16S rRNA forms the backbone of the small (30S) ribosomal subunit, providing the decoding center for mRNA/tRNA pairing; 23S rRNA and 5S rRNA form the catalytic core of the large (50S) subunit, orchestrating peptide bond formation and ensuring correct polypeptide exit[2][1]. Ribosomal RNA is transcribed from ribosomal DNA and binds specifically to ribosomal proteins to assemble ribosomal subunits. Its sequence and structure are highly conserved, but the distinct bacterial rRNA allows selective targeting by antibiotics. Minor nucleotide modifications of bacterial rRNAs contribute to ribosome stability and may affect drug susceptibility[3][1]. In *Lactobacillus*, as in other bacteria, rRNA is non-coding and is fundamental for protein synthesis and cell viability[2][1].
- Other names
- Bacterial rRNA16S rRNA23S rRNA5S rRNA
02
Mechanism of action
Drugs inhibit ribosomal function by binding to functional sites on rRNA, thereby blocking mRNA translation, tRNA binding, or peptide elongation
03
Biological functions
Catalysis of peptide bond formation (peptidyl transferase activity)Structural framework for ribosome assemblyBinding and positioning of mRNA and tRNA during translationRegulation of translation and gene expression (via methylation and organization)
04
Disease associations
Infection: targeted by antibiotics to inhibit bacterial growthOther: Antibiotic resistance can develop due to rRNA mutations
05
Safety considerations
Bacterial rRNA targeting antibiotics sometimes affect mitochondrial rRNA in humans, leading to toxicity (ototoxicity, nephrotoxicity); however, bacterial rRNA is generally distinct enough to be selectively targetedResistance can emerge via mutations or methylation alterations in rRNA, reducing drug efficacy
06
Interacting drugs
Aminoglycosides (e.g., gentamicin, streptomycin): bind 16S rRNA in the decoding center of the 30S subunit
3 more in the full profile.
07
Biomarkers
16S rRNA gene: used extensively for bacterial identification and taxonomy, including for *Lactobacillus*Methylation status of rRNA: can indicate susceptibility to antibiotics and ribosome assembly integrity
Beyond the preview
Go deeper on Ribosomal RNA from Lactobacillus (rRNA (not specific to Lactobacillus, but used for ribosomal RNA generally)).
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Clinical trials
Full profile accessFollow the clinical studies evaluating therapies directed at this target.
- Trial design
- Status
- Readouts
Competitive landscape
Full profile accessCompare approaches across drug candidates, modalities, and indications.
- Programs
- Modalities
- Indications
Literature & evidence
Full profile accessInvestigate the research and source evidence behind target biology and development.
- Publications
- Sources
- Analysis
Patents
Full profile accessExplore patent activity around therapies and technologies addressing this target.
- Patents
- Assignees
- Technologies
Research & analysis
Full profile accessConnect target biology, drug development, and emerging evidence in your research.
- Biology
- Development news
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on Ribosomal RNA from Lactobacillus (rRNA (not specific to Lactobacillus, but used for ribosomal RNA generally)).