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Target intelligence / Profile preview
Ribosomal S6 Kinase (RSK)
- Target
- RSK
- Molecular classification
- Enzyme, Serine/threonine kinase, AGC kinase family
01
Overview
Ribosomal S6 kinase (RSK) refers to a family of serine/threonine protein kinases that play key roles in signal transduction, particularly in the regulation of cell growth, proliferation, metabolism, and survival. RSKs are activated by upstream signaling pathways such as the MAPK/ERK pathway and mTORC1 pathway. They phosphorylate ribosomal protein S6, thereby promoting translation initiation. RSKs regulate fundamental cellular processes including cell growth, proliferation, protein synthesis, and glucose homeostasis and their dysregulation is implicated in diseases like cancer and metabolic disorders.
- Other names
- p90 Ribosomal S6 Kinasep70 S6 KinaseMAPK-activated protein kinase-1MAPKAP-K1S6KS6-H1 Kinase
02
Mechanism of action
Inhibition of kinase activity, disruption of downstream signaling
03
Biological functions
Signal transductionCell growthCell proliferationProtein synthesisLipid synthesisGlucose homeostasisInsulin sensitivityTranslation initiationMetabolism
04
Disease associations
CancerMetabolic disordersObesityHypertrophic cardiomyopathyInsulin resistance
05
Safety considerations
Potential for off-target effects due to broad substrate specificityInhibition may affect multiple cellular processes
06
Biomarkers
Phosphorylation of ribosomal protein S6Phosphorylation of Thr389 on p70S6 kinase
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