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Target intelligence / Profile preview
Ribosomal S6 Kinase Alpha-1 (RPS6KA1)
- Target
- RPS6KA1
- Molecular classification
- Serine/threonine-protein kinase, RSK family, Enzyme
01
Overview
Ribosomal S6 kinase alpha-1 (RPS6KA1) is a serine/threonine protein kinase that belongs to the RSK (ribosomal S6 kinase) family. It phosphorylates a variety of substrates, including components of the mitogen-activated protein kinase (MAPK) signaling pathway, influencing cell growth, survival, differentiation, and motility. Alterations in RPS6KA1 are associated with Coffin-Lowry Syndrome and Tuberous Sclerosis, and it is implicated in insulin resistance.
- Other names
- RSK1MAPKAPK1p90RSK1
02
Mechanism of action
RPS6KA1 phosphorylates a variety of substrates involved in cell growth, survival, differentiation, and motility, including components of the mitogen-activated protein kinase (MAPK) signaling pathway. Inhibition would likely affect downstream signaling.
03
Biological functions
Cell growthCell survivalCell differentiationCell motilityApoptosis regulationCell cycle progressionSignal transduction
04
Disease associations
Coffin-Lowry SyndromeTuberous SclerosisInsulin resistanceMetabolic disorders
05
Safety considerations
Potential for off-target effects due to kinase activity.Inhibition could disrupt multiple signaling pathways.
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