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Target intelligence / Profile preview
Ribosome production factor 1 homolog (RPF1)
- Target
- RPF1
- Molecular classification
- Other, Brix domain-containing protein, RNA-binding protein
01
Overview
Ribosome production factor 1 homolog (RPF1) is a nucleolar protein involved in the maturation of ribosomal RNA (rRNA), specifically contributing to the processing and maturation of 5.8S and large subunit (LSU) rRNA, which are essential steps in ribosome biogenesis[3][6]. RPF1 contains a Brix domain, a conserved motif found in proteins associated with ribosome assembly and biogenesis[6]. In humans, RPF1 is located in the nucleolus and enables RNA binding activity, and predicted roles include facilitating the assembly and export of the large ribosomal subunit[3][5][6]. There is no current evidence that RPF1 is a direct therapeutic target or interacts with any approved drugs.
- Other names
- Ribosome production factor 1BXDC5Brix domain-containing protein 5Ribosome biogenesis protein RPF1RNA processing factor 12310066N05Rik
02
Biological functions
rRNA maturationRibosome biogenesisRNA bindingCell differentiationCarbohydrate derivative metabolism
03
Disease associations
Other (no direct evidence for roles in cancer, inflammation, neurodegeneration, cardiovascular disease, or infection reported in available sources)
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