Target intelligence / Profile preview

Ricin A Chain (RTA)

Target: RTA
Molecular classification: Enzyme, N-glycoside hydrolase, AB Toxin (A component)

Overview

Ricin A chain (RTA) is the enzymatically active subunit of the ricin toxin. It functions as an N-glycoside hydrolase, depurinating ribosomal RNA and inhibiting protein synthesis, leading to cell death. While highly toxic in the context of the holotoxin, isolated RTA is being explored for targeted cancer therapy as an immunotoxin payload due to its ability to inhibit protein synthesis without efficient cellular uptake, mitigating its overall toxicity.

Mechanism of action

N-glycosidase activity leading to ribosomal inactivation

Biological functions

Inhibition of protein synthesisRibosomal RNA depurinationCell death induction

Disease associations

Cancer (potential therapeutic target)Toxicity

Safety considerations

High toxicity if not targetedOff-target effects of immunotoxins

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