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Target intelligence / Profile preview
Rictor-mTOR protein complex (mTORC2)
- Target
- mTORC2
- Molecular classification
- Protein complex, Kinase complex
01
Overview
The Rictor-mTOR protein complex (mTORC2) is a multi-protein complex containing mTOR that integrates signals from nutrients and growth factors to regulate cell growth, metabolism, survival, and cytoskeletal organization. It phosphorylates AGC family kinases such as Akt, SGK1, and certain isoforms of PKC. Unlike mTORC1, mTORC2 contains RICTOR and is generally insensitive to acute rapamycin treatment. Dysregulation of mTORC2 has been implicated in cancer and metabolic diseases.
02
Mechanism of action
Phosphorylation/activation of AGC kinases (AKT(Ser473), SGK1, PKC)
03
Biological functions
Signal transductionCell proliferationCell survivalMetabolism regulationCytoskeletal organizationGrowth factor response
04
Disease associations
CancerMetabolic diseasesDiabetesProliferative disorders
05
Safety considerations
Lack of selective inhibitorsAberrant Akt signaling
06
Interacting drugs
Perifosine
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