Rift Valley fever virus envelope glycoprotein Gc (Gc)

Rift Valley fever virus envelope glycoprotein Gc is an essential structural component responsible for mediating viral-host cell membrane fusion during infection. Its function depends heavily on pH-induced structural rearrangements typical of class II viral fusion proteins. Glycosylation enhances its ability to interact with specific cellular receptors involved in immune evasion or enhanced infectivity. As a key antigenic determinant targeted by neutralizing antibodies—and due to its central role in pathogenesis—it represents an important target for antiviral strategies including vaccine development or therapeutic inhibition using peptide-based approaches.

Inhibition of membrane fusion