RIMS binding protein 2 (RIMBP2)

RIMS binding protein 2 (RIMBP2) is a modular adaptor and scaffolding protein found at the presynaptic active zone of neurons, where it links voltage-gated calcium channels and synaptic release machinery to organize and regulate neurotransmitter release[1][2][3][4][5][6]. It features multiple SH3-domains and fibronectin III repeats, supporting its role as a scaffold for coupling Ca²⁺ channel influx with vesicle exocytosis and ensuring precise synaptic signaling[1][2][5]. RIMBP2 is essential for organizing the presynaptic active zone, modulating calcium channel abundance and coupling to release sites, thus influencing release probability and synaptic plasticity[2][4][5][6]. Dysregulation or mutation of RIMBP2 has been linked to various neurological disorders, including Pitt-Hopkins syndrome, specific hereditary deafness, and centronuclear myopathy[3][6]. Despite its critical role in synaptic transmission, RIMBP2 itself is not recognized as a direct therapeutic target for available drugs[1][3][6].

Other names

RIM-BP2PPP1R133KIAA0318RBP2MGC15831protein phosphatase 1 regulatory subunit 133