Drug pipeline
Full profile accessExplore the programs pursuing this target and their development progress.
- Drug candidates
- Developers
- Development stage
Target intelligence / Profile preview
Ring finger protein 138 (RNF138)
- Target
- RNF138
- Molecular classification
- Enzyme, RING finger protein
01
Overview
Ring finger protein 138 (RNF138) is an E3 ubiquitin-protein ligase that mediates protein ubiquitination, thereby signaling proteins for degradation via the proteasome. It is involved in DNA damage response and repair by promoting homologous recombination, regulates transcription by targeting key transcription factors like C/EBPα, and is implicated in the differentiation arrest of myeloid cells in acute myeloid leukemia. RNF138 also modulates the NF-κB signaling pathway, with downregulation linked to poorer prognosis and increased tumor progression in diseases such as colorectal cancer. RNF138 is a member of the RING finger protein family characterized by the RING domain, essential for substrate protein recognition and E2-E3 ligase activity. Its dysfunction is associated with cancer, immune dysregulation, and potentially neurodegenerative conditions.
- Other names
- RNF138
02
Biological functions
Ubiquitin-mediated proteolysisDNA damage response and homologous recombinationRegulation of transcriptionRegulation of cell differentiationNegative regulation of NF-κB signaling
03
Disease associations
CancerNeurodegenerative diseaseInflammation
04
Biomarkers
RNF138 mRNA expression levels
Beyond the preview
Go deeper on Ring finger protein 138 (RNF138).
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Clinical trials
Full profile accessFollow the clinical studies evaluating therapies directed at this target.
- Trial design
- Status
- Readouts
Competitive landscape
Full profile accessCompare approaches across drug candidates, modalities, and indications.
- Programs
- Modalities
- Indications
Literature & evidence
Full profile accessInvestigate the research and source evidence behind target biology and development.
- Publications
- Sources
- Analysis
Patents
Full profile accessExplore patent activity around therapies and technologies addressing this target.
- Patents
- Assignees
- Technologies
Research & analysis
Full profile accessConnect target biology, drug development, and emerging evidence in your research.
- Biology
- Development news
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on Ring finger protein 138 (RNF138).