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Target intelligence / Profile preview
Ring finger protein 150 (RNF150)
- Target
- RNF150
- Molecular classification
- Other, E3 ubiquitin-protein ligase, RING finger protein family
01
Overview
Ring finger protein 150 (RNF150) is a protein-coding gene in humans encoding a member of the RING finger protein family, characterized by a C3HC4-type zinc finger motif involved in mediating protein–protein interactions essential for ubiquitin ligase activity. RNF150 functions as a predicted E3 ubiquitin ligase participating in the ubiquitin-dependent catabolic process, likely regulating substrate specificity for protein degradation pathways in the cytoplasm and at membrane structures. Expression patterns show that RNF150 may play a role in suppressing tumor cell proliferation via promoting target protein ubiquitination and downregulation of pathways such as p38 MAPK signaling, with evidence suggesting a function as a prognostic biomarker in certain cancers, notably gastric and papillary thyroid carcinoma. Despite these roles, the precise biological targets and physiological substrates of RNF150 remain incompletely defined, and it is not an established therapeutic target in current clinical practice.
- Other names
- KIAA1214RING finger protein 150
02
Biological functions
Ubiquitin-dependent protein catabolic processRegulation of protein stabilityProtein ubiquitinationCell proliferation (including suppression effects in thyroid and gastric cancer models)Cell apoptosis (through ubiquitination targets affecting pathways like p38 MAPK and ASK1)Heparin binding/activity pathway implication in gastric cancer
03
Disease associations
Cancer (including gastric cancer and papillary thyroid carcinoma; may act as a prognostic biomarker)Other (Carotid artery dissection association is minor; no large body of disease association outside oncology)
04
Biomarkers
Prognostic biomarker in gastric cancer (particularly in microsatellite instability (MSI) subtypes: low RNF150 expression is associated with better prognosis)Prognostic marker in papillary thyroid carcinoma (higher expression associated with favorable outcome)
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