Ring finger protein 151 (RNF151)

Ring finger protein 151 (RNF151) is a predicted protein-coding gene that encodes a RING-type E3 ubiquitin ligase, characterized by a C3HC4-type RING finger domain essential for mediating protein-protein interactions and promoting ubiquitination[1][2][3][9]. It is primarily expressed in testis tissue (notably in mice, with orthologs in humans), where it localizes to the nucleus and is implicated in the later steps of spermatogenesis, particularly elongating spermatids[2][7]. RNF151 interacts with dysbindin, a protein involved in membrane biogenesis, suggesting a possible role in acrosome formation during sperm development[2]. There is currently no evidence that RNF151 is a validated therapeutic target in humans, nor are there any known drugs or established disease associations; it is not listed among standard targets for receptor, enzyme, transporter, or other classical druggable protein classes[1][3][9]. This gene is sometimes ambiguous in databases, with incomplete data for its biological or clinical significance.

Other names

ring finger protein 1511700010O16RIK