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Ring finger protein 168 pseudogene
- Molecular classification
- Pseudogene, Non-coding RNA
01
Overview
Ring finger protein 168 pseudogene (ENSG00000225240) is a non-functional genomic element in human, originating from duplication or retrotransposition of the RNF168 gene. It does not encode a protein, but its sequence shares high similarity with the functional RNF168 gene, which is involved in DNA damage signaling; the pseudogene itself does not participate in any known biological processes or diseases. Its main relevance is as a technical confounder in molecular diagnostics, where its similarity may cause issues in detecting genuine RNF168 variants. There is no evidence that this pseudogene itself is transcribed, translated, or functional.
- Other names
- RNF168 pseudogeneAC117490.1Ring finger protein 168 (RNF168) pseudogene
02
Biological functions
None establishedPossible transcriptional activity or regulatory roles (inferred for some pseudogenes, but not established for this locus)
03
Disease associations
None directly; pseudogenes, including this one, have no direct causal role in diseasesPseudogene sequences can interfere with molecular diagnostics, potentially complicating detection of mutations in the functional RNF168 gene
04
Safety considerations
Can contribute to false-positive or false-negative results in gene sequencing and variant detection targeting the parent RNF168 gene, due to high sequence similarity
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