Ring finger protein 175 (RNF175)

Ring finger protein 175 (RNF175) is a membrane-associated E3 ubiquitin-protein ligase of the RING finger family, characterized by its zinc finger RING domain which confers ubiquitin ligase activity, and additional FYVE and PHD motifs suggesting roles in phospholipid binding and chromatin-mediated transcriptional regulation. RNF175 is primarily expressed in the brain and is highly present in neuronal and glial cells, although it also plays roles in inflammatory responses (upregulated in neutrophils) and interacts directly with cytoskeletal proteins and co-chaperones active in ERAD. Its closest paralog is RNF121, with which it shares functional homology and pathway associations. RNF175 is predicted to reside and function at cellular membranes, especially the endoplasmic reticulum and Golgi, where it is involved in the ubiquitin-dependent degradation of misfolded proteins, thus influencing cell survival, division, and possibly cancer progression. While RNF175 is a plausible therapeutic target given its disease-related expression and cellular roles, it is currently uncharacterized in terms of clinical druggability and direct pharmacological targeting.

Other names

RNF175FLJ34190Ring finger protein 175GC04M154989GC04M154850GC04M154631GC04M150362UniProtKB: Q8N4F7NCBI Gene: 285533HGNC: 27735

Not established for drugs specifically targeting RNF175; mechanisms inferred from E3 ligase activity including regulation of protein degradation and modulation of cellular signaling pathways.