Ring finger protein 222 (RNF222)

Ring finger protein 222 is a predicted protein coding gene in humans (HGNC:34517), belonging to the RING finger (RNF) protein family[1][6]. Members of this family typically function as E3 ubiquitin ligases, contributing to ubiquitination of substrate proteins, which modulates cellular processes such as protein degradation, signal transduction, and transcriptional regulation[2]. RNF222 is predicted to bind metal ions, likely zinc, and to be an integral membrane protein[3][5][6]. There is no direct experimental evidence regarding the specific biological function or disease mechanism for RNF222, but genetic association data link it to Moyamoya disease 1[1]. No drugs, biomarkers, or safety profiles are characterized for RNF222, and it is not currently recognized as a therapeutic target. Its classification is based on sequence prediction and family membership rather than critical functional characterization. RNF222 should not be confused with RNF2 (Ring finger protein 2), which is a distinct protein with validated functions[1][6].

Other names

Ring finger protein 222RNF222RING finger protein 222RING finger protein LOC643904