Drug pipeline
Full profile accessExplore the programs pursuing this target and their development progress.
- Drug candidates
- Developers
- Development stage
Target intelligence / Profile preview
Ring finger protein 223 (RNF223)
- Target
- RNF223
- Molecular classification
- E3 ubiquitin-protein ligase, RING finger protein family, Enzyme
01
Overview
Ring finger protein 223 (RNF223) is a member of the RING finger family of E3 ubiquitin-protein ligases, which catalyze the transfer of ubiquitin from E2 enzymes to specific substrate proteins, thereby regulating their degradation, stability, and cellular localization[4][5]. RNF223 is upregulated in pancreatic cancer, where it acts as an oncogene, promoting tumor growth and cell migration through effects on cancer cell metabolism and proliferation[1][2]. Its expression appears to be upregulated by the transcription factor KLF4. RNF223 is considered an independent prognostic marker in pancreatic cancer and may contribute to the pathogenesis of other malignancies, such as uterine sarcoma and endometrial cancer[2]. No approved drugs currently target RNF223 directly, and its clinical relevance is emerging in the context of cancer biology.
- Other names
- RNF223RING finger protein 223
02
Mechanism of action
Modulation of ubiquitin-proteasome pathway; Regulation of protein stability via ubiquitination
03
Biological functions
Protein ubiquitinationRegulation of cell metabolismRegulation of cell proliferationCell migrationSignal transduction
04
Disease associations
CancerPancreatic cancer (oncogene, promotes proliferation and migration)Uterine sarcoma (prognostic marker)Endometrial cancer (mutation associated with clinical features)
05
Safety considerations
Potential as an oncogenic driver—targeting could affect cellular metabolism and proliferation, leading to possible safety concerns in normal tissue[1][2]
06
Biomarkers
Predictive/prognostic marker for pancreatic cancer progression[1][2]Prognostic significance in uterine sarcoma and endometrial cancer[2]
Beyond the preview
Go deeper on Ring finger protein 223 (RNF223).
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Clinical trials
Full profile accessFollow the clinical studies evaluating therapies directed at this target.
- Trial design
- Status
- Readouts
Competitive landscape
Full profile accessCompare approaches across drug candidates, modalities, and indications.
- Programs
- Modalities
- Indications
Literature & evidence
Full profile accessInvestigate the research and source evidence behind target biology and development.
- Publications
- Sources
- Analysis
Patents
Full profile accessExplore patent activity around therapies and technologies addressing this target.
- Patents
- Assignees
- Technologies
Research & analysis
Full profile accessConnect target biology, drug development, and emerging evidence in your research.
- Biology
- Development news
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on Ring finger protein 223 (RNF223).