Ring finger protein 227 (RNF227)

Ring finger protein 227 (RNF227) is a small, zinc finger domain-containing protein encoded by the RNF227 gene on chromosome 17p13.1. The protein contains a RING-type zinc finger domain (residues 18–81), which is highly conserved among eukaryotes and typical of E3 ubiquitin ligases. It is predicted to mediate ubiquitin protein ligase activity and to participate in protein ubiquitination, suggesting a possible role in protein turnover, cell signaling, or other ubiquitin-dependent processes[1][3][7]. RNF227 is expressed in various tissues with relatively higher levels in skin, testis, brain, intestine, and kidney[1][5]. Some studies have observed its differential expression in conditions such as obesity, ERBB2-positive breast cancer cell lines, and keratinocyte proliferation models, but no direct, targetable disease association or established physiological role is currently known. Previous naming confusion exists with "LINC02581," which was annotated as a long intergenic non-coding RNA; current nomenclature assigns protein-coding roles to RNF227, while LINC02581 may persist as a historical alias[1][3]. There are no known drugs, biomarkers, or established safety considerations related to RNF227. Key facts: - Not an established therapeutic target, receptor, or enzyme - Member of the RING finger protein family, potentially involved in ubiquitination - Some expression/regulation data in cancer, obesity, and developmental tissues, but no validated druggability or disease targeting If you require more structured output or information on curation standards due to the LINC02581 overlap, explicit reference to HGNC and latest NCBI/Ensembl curation is recommended[3][4][7].

Other names

RING finger protein 227RNF227LINC02581