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Target intelligence / Profile preview
Ring finger protein 43
- Molecular classification
- Enzyme, E3 ubiquitin ligase
01
Overview
Ring finger protein 43 (RNF43) is a RING-type E3 ubiquitin ligase that acts as a negative regulator of the Wnt signaling pathway. It promotes the ubiquitination and endocytosis of frizzled receptors, leading to their removal from the cell surface and downregulation of Wnt signaling. Mutations in *RNF43* are frequently found in various cancers, and its altered expression may impact DNA repair capacity.
- Other names
- RNF124URCCSSPCS
02
Mechanism of action
RNF43 mutations can sensitize cancer cells to Wnt antagonists by increasing Wnt pathway dependency.
03
Biological functions
UbiquitinationEndocytosisNegative regulation of canonical Wnt/β-catenin pathwayDNA double-strand break repair (NHEJ)
04
Disease associations
Cancer (colorectal, pancreatic)
05
Safety considerations
Potential for off-target effects of Wnt inhibitorsDevelopment of resistance to Wnt inhibitors
06
Biomarkers
RNF43 mutations (for predicting response to Wnt inhibitors)RNF43 expression levels
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