RIPOR family member 3 (RIPOR3)

RIPOR family member 3 (RIPOR3), also known as FAM65C and designated as C20orf175/C20orf176, is a member of the RIPOR family of RHO GTPase-interacting proteins[1][2]. It is a protein-coding gene with structural domains related to RHO GTPase binding, characterized by a conserved RHO-binding motif similar to other family members (RIPOR1, RIPOR2), which negatively regulate RHO GTPase activity and thus influence processes like cell migration and polarity[1]. However, unlike RIPOR1 and RIPOR2, the **biological functions of RIPOR3 are not well elucidated**; current evidence is drawn mainly from expression studies and homology to its relatives[1][2]. Expression data show that RIPOR3 is widely distributed across human tissues and is implicated in regulation of immune signaling pathways[2]. Recent studies associate RIPOR3 with prognosis in cancers (particularly tongue squamous cell carcinoma), where high expression predicts better survival[2]. Its alteration at the epigenetic level (methylation) is also noted in aging and cancer. There is currently **no experimental evidence for molecular function annotation, interacting drugs, or established mechanisms of action for RIPOR3**[4][2][3]. No known adverse safety or therapeutic challenges have yet been described[2].

Other names

C20orf175C20orf176FAM65CdJ530I15.2dJ530I15.3protein FAM65Cfamily with sequence similarity 65 member C