Ripply transcriptional repressor 1 (RIPPLY1)

Ripply transcriptional repressor 1 (RIPPLY1) is a nuclear protein that acts as a transcriptional repressor, particularly by interacting with the transcriptional corepressor Groucho[5]. It is essential for the proper transition from presomitic mesoderm to somites during embryonic development, terminating segmental gene expression and maintaining the rostrocaudal polarity of somites[5][3][4][2]. RIPPLY1 is expressed in the nucleus of developing tissues and is involved in negative regulation of transcription, somite boundary formation, and skeletal muscle development[2][3][4]. Mutations in the human ortholog are implicated in certain congenital vertebral malformation syndromes, such as spondylocostal dysostosis[2]. There is no current evidence indicating that RIPPLY1 is a direct therapeutic target or interacts with drugs in clinical use[4][6].

Other names

Protein ripply1ripply1ripply1 homolog