Ripply transcriptional repressor 2 (RIPPLY2)

Ripply transcriptional repressor 2 (RIPPLY2) is a nuclear protein and member of the Ripply family involved in vertebrate somitogenesis and segmentation of the axial skeleton. RIPPLY2 contains a WRPW tetrapeptide motif, essential for interaction with the transcriptional co-repressor Groucho, and a C-terminal homology domain critical for its function. RIPPLY2 modulates transcription of T-box family transcription factors, such as Tbx6, often by recruiting the 26S proteasome complex to degrade these proteins in a highly tissue- and context-specific manner, especially in presomitic mesoderm (PSM) cells. Mutations or loss of RIPPLY2 disrupt normal somite formation and patterning, leading to conditions such as spondylocostal dysostosis. Though mechanistically important in embryogenesis, RIPPLY2 is not currently recognized as a clinical drug target, nor is it associated with known pharmacological agents, mechanisms, or safety concerns in a therapeutic setting

Other names

Protein ripply2C6orf159SCDO6dJ237I15.1ripply2 homologRIPP2

Not applicable. No drugs known to target RIPPLY2