RLIG1 pseudogene 2 (RLIG1P2)

RLIG1P2 is annotated as a pseudogene that is related by homology to RLIG1 (RNA 5'-phosphate and 3'-OH ligase 1), which is an ATP-dependent RNA ligase involved in RNA repair and tRNA biology[1][3][4]. However, RLIG1P2 itself does not encode a functional protein and is not classified as a therapeutic target, receptor, enzyme, transporter, or any other category of active biomolecule. Functional roles, disease associations, interacting drugs, and clinical biomarkers are unknown and would not be expected for a pseudogene unless demonstrated to have regulatory or pathological activity, which is not the case here based on available data. “RLIG1 pseudogene 2” may represent a misannotation or database placeholder rather than a targetable gene product or receptor. **Detailed rationale and clarification:** - RLIG1 is a bona fide protein-coding gene with enzymatic activity as a 5’ to 3’ RNA ligase, involved in RNA repair, particularly tRNA ligation, and is implicated in cell survival under oxidative stress. RLIG1 has structural and functional characterization and has been studied as a potential enzyme inhibitor target[1][2][3][4]. - RLIG1P2, by contrast, appears only as a pseudogene related entry and is not cited in major biological databases, functional studies, or disease literature as a target or as having biochemical or therapeutic significance. - There is no evidence that RLIG1P2 encodes a functional protein or RNA, is expressed, or is implicated in disease or drug interactions. - The correct therapeutic target, if of interest, would be RLIG1 (RNA 5'-phosphate and 3'-OH ligase 1), not its pseudogene. **Summary:** RLIG1 pseudogene 2 (RLIG1P2) is not a protein, receptor, or therapeutic target; it is a probable pseudogene with no established biological or medical relevance[3]. For functional studies or drug discovery, the focus should be on RLIG1, not RLIG1P2.

Other names

RLIG1P2