RN7SK pseudogene 121 (RN7SKP121)

RN7SK pseudogene 121 (RN7SKP121) is a non-coding RNA pseudogene located on chromosome 11 (chr11:127406028-127406332, hg38)[1]. It is homologous to the functional 7SK small nuclear RNA (RN7SK), which plays a regulatory role in transcription elongation by binding and inhibiting the P-TEFb complex (CDK9/cyclin T1)[3]. In contrast, RN7SKP121 does not encode a functional RNA or protein, and there is no evidence it participates in cellular functions, disease mechanisms, or serves as a drug target[1][2]. Pseudogenes such as RN7SKP121 are typically remnants of genomic evolution and are included in gene annotations mainly for completeness. Functional studies, therapeutic strategies, and drug discovery efforts do not highlight this pseudogene as relevant.

Other names

RNA, 7SK small nuclear pseudogene 121RN7SKP121