RN7SK pseudogene 145 (RN7SKP145)

RN7SK pseudogene 145 (RN7SKP145) is a pseudogene commonly annotated in genomic databases as a sequence similar to functional 7SK small nuclear RNA genes. Unlike the functional 7SK RNA, which mediates regulation of transcription elongation by controlling the positive transcription elongation factor P-TEFb[1][3], RN7SKP145 does not encode a functional RNA and has no known biological role. Pseudogenes such as RN7SKP145 are typically non-functional remnants of functional genes and are not considered drug targets, biomarkers, or involved in disease mechanisms. If the query is meant to refer to the functional 7SK small nuclear RNA (RN7SK), this molecule is part of the 7SK snRNP, which regulates transcription elongation and participates in gene expression, HIV transcriptional activation, and presents molecular interactions with proteins such as HEXIM, BRD4, and HIV Tat[1][3]. However, RN7SKP145 is a pseudogene and not synonymous with RN7SK; therefore, the information provided above accurately reflects its status.

Other names

RN7SKP145RNA, 7SK small nuclear pseudogene 145