RN7SK pseudogene 173 (RN7SKP173)

RN7SK pseudogene 173 is annotated as a pseudogene in human genomic databases, signifying it is a sequence similar to the functional RN7SK gene but does not encode a functional small nuclear RNA or protein. The true RN7SK gene encodes 7SK snRNA, an abundant noncoding RNA that plays a central regulatory role in RNA polymerase II-mediated transcription by controlling the positive transcription elongation factor b (P-TEFb)[1][5][3][4]. However, pseudogenes such as RN7SKP173 generally lack transcriptional activity or coding potential and are not considered functional targets for therapeutic intervention, drug development, or biomarker identification. Given the designation "pseudogene," RN7SKP173 is not a canonical drug target and should not be confused with functionally characterized molecules[5]. The entry is likely erroneous or not relevant for biological or therapeutic targeting. For reference, the genuine **RN7SK small nuclear RNA** (not this pseudogene) is a critical regulator of transcription elongation, involved in sequestration and inhibition of P-TEFb, and dysregulation of RN7SK function is linked to cancer, heart disease, developmental disorders, and viral infection[1][2][3][4][5].

Other names

RN7SKP1737SK pseudogene 173RN7SKP173 (NCBI, HGNC-like pseudogene symbols)