RN7SK pseudogene 260 (RN7SKP260)

RN7SK pseudogene 260 is a genomic sequence classified as a pseudogene of the 7SK small nuclear RNA family in humans[3]. Pseudogenes like RN7SKP260 arise from duplication or retrotransposition of functional RNA genes but typically lack the capability to produce a functional product due to mutations, truncation, or lack of regulatory sequences[5]. Unlike the functional RN7SK (involved in transcriptional regulation and snRNP complexes[1]), RN7SKP260 does not encode a functional RNA and is not known to have a direct biological or pathological role. It is not considered a therapeutic target, and no interacting drugs, biomarker roles, or clinical safety data are associated with it[3][6]. RN7SKP260 is not a functional gene; it is a pseudogene, which means it shares sequence similarity with the functional RN7SK gene but is non-coding and lacks active biological function[3][5]. The functional RN7SK small nuclear RNA regulates transcription elongation by RNA polymerase II via its role in complexes that sequester P-TEFb, but this is not true for its pseudogene variants[1][2][6]. No current evidence classifies RN7SKP260 as a therapeutic target, nor is it associated with specific diseases or drug interactions[3][6].

Other names

RNA, 7SK small nuclear pseudogene 260RN7SKP260