RN7SK pseudogene 297 (RN7SKP297)

RN7SK pseudogene 297 (RN7SKP297), also known as RNA, 7SK small nuclear pseudogene 297, is a pseudogene related to the functional 7SK small nuclear RNA. It is not considered an active therapeutic target, nor does it possess verified biological functions or disease associations. RN7SKP297 is annotated in genomics databases as a non-functional copy (pseudogene) of the RN7SK gene, which encodes the 7SK small nuclear RNA. The canonical functional gene, 7SK RNA, is an abundant small nuclear noncoding RNA found in metazoans, and it plays an important role in regulating transcription elongation by controlling positive transcription elongation factor b (P-TEFb) activity. The pseudogene RN7SKP297 does not produce a functional RNA or protein, has no known biological activity, and is not implicated in human disease nor targeted by any pharmacological agents. As such, it is not considered a receptor, enzyme, transporter, or any conventional therapeutic target. The related, functional 7SK RNA regulates gene expression and has disease relevance through its control of P-TEFb, with dysregulation linked to cancer, cardiovascular disease, developmental disorders, and viral infection (notably HIV). However, RN7SKP297 itself does not share these functions—it is an inactive genomic element with no established biological or clinical significance.

Other names

RNA, 7SK small nuclear pseudogene 297